The basis of Tissue factor pathway inhibitor (TFPI)
نویسندگان
چکیده
منابع مشابه
Recent Progress on Tissue Factor Pathway Inhibitor (TFPI)
外 因 系凝 固 の 開 始 反 応 で あ る組 織 因子 に よ る VII因 子 お よびX因 子 の 活 性 化 を特 異 的 に 阻 害 す る プ ロ テ ア ー ゼ イ ン ヒ ビタ ー の 存 在 は 古 くか ら指 摘 さ れ て きた が,そ の性 質 は長 い 間 明 らか で は な か っ た.そ の後,Brozeら の研 究 に よ り, そ の イ ン ヒ ビタ ー はXa因 子 依 存 性 にVII因 子 の 活 性 化 を阻 害 す る作 用 を もつ とい う一 見,極 め て 奇 妙 な イ ン ヒ ビタ ー で あ る こ とが 明 らか に な っ て きた.1988年 に彼 らに よ り,そ の ア ミノ 酸 配 列 が 決 定 さ れ,そ れ 以 後,い くつ か の グル ー プ に よ り ,そ の組 換 え体 が 調 製 され た ...
متن کاملLow levels of tissue factor pathway inhibitor (TFPI) increase the risk of venous thrombosis.
There is now strong experimental evidence that tissue factor pathway inhibitor (TFPI) is a critical inhibitor to modulate tissue factor-induced coagulation, but the role of TFPI as a risk factor for thrombosis is yet to be to be determined. This study investigated the role of low TFPI levels for the development of deep-vein thrombosis (DVT). We determined TFPI activity and TFPI-free and total a...
متن کاملInhibition of tissue factor pathway inhibitor (TFPI) by ARC19499 improves clotting of hemophiliac blood
Background Hemophilia A and B are disorders resulting from a deficiency in factor VIII (FVIII), and factor IX (FIX), respectively. Tissue Factor (TF) is a key component of the extrinsic pathway and plays a role in the coagulation defect of hemophilic blood. Neutralizing the activity of TFPI represents a promising treatment concept in patients with hereditary or acquired hemophilia. ARC19499 is ...
متن کاملCloning, expression, and characterization of mouse tissue factor pathway inhibitor (TFPI).
Tissue factor pathway inhibitor (TFPI) acts to regulate the initiation of coagulation by first inhibiting factor Xa. The complex of factor Xa/TFPI then inhibits the factor VIIa/tissue factor complex. The cDNA sequences of TFPI from several different species have been previously reported. A high level of similarity is present among TFPIs at the molecular level (DNA and protein sequences) as well...
متن کاملA novel anticoagulant activity assay of tissue factor pathway inhibitor I (TFPI).
Tissue factor (TF) pathway inhibitor I (TFPI) is the physiological inhibitor of TF-induced blood coagulation. Circulating blood contains full-length TFPI and TFPI truncated at the C-terminal end. Previous studies have shown that full-length TFPI exerts a stronger anticoagulant effect on diluted prothrombin time (DPT) than truncated TFPI, and it has been suggested that full-length TFPI is biolog...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 2014
ISSN: 0915-7441,1880-8808
DOI: 10.2491/jjsth.25.5